Inflammasome: Putting the Pieces Together
نویسنده
چکیده
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.
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ورودعنوان ژورنال:
- Cell
دوره 156 شماره
صفحات -
تاریخ انتشار 2014